The main focus includes all the targetable S2 elements, namely, the fusion peptide, stem helix, and heptad repeats 1 and 2 (HR1-HR2) bundle. Here, we summarize the most recently developed broad-spectrum fusion inhibitors (e.g., nAbs, peptides, proteins, and small-molecule compounds) and candidate vaccines targeting the conserved elements in SARS-CoV-2 S2 subunit. Hence, S2-based therapeutics may provide effective cross-protection against new SARS-CoV-2 variants. In sharp contrast to the massive accumulation of mutations within the SARS-CoV-2 receptor-binding domain (RBD), the S2 fusion subunit has remained highly conserved among variants. Therefore, exploring broad-spectrum antiviral agents to combat the emerging variants is imperative. This has posed new challenges for the prevention and treatment of COVID-19. Of special note is the recently expanding Omicron subvariants that are capable of immune evasion from most of the existing neutralizing antibodies (nAbs). Rapid viral antigenic evolution has led to the continual generation of new variants. Guest OS is Windows XP MCE SP2, with 1.5GB of RAM allocated to it.The ongoing global pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), has caused devastating impacts on the public health and the global economy. Moving to the smaller one doesn't make any difference - even dropping below 1024x768 as the OP suggested.īasically, moving windows around is choppy. Note that I'm using VMware on the larger of the two screens.
Unfortunately I didn't run VMWare before the graphics update, so I can't say which caused it. I've just updated to10.5.2 with the subsequent Leopard Graphics Update. Yup - I'm seeing this too (I've got an eval copy of Fusion, Version 1.1 (62573) - my full copy is on the way from Amazon!